News about hearing loss, tinnitus, balance and other inner ear issues
| Company | Target/Method | Goal |
|---|---|---|
| Frequency Tx (Boston) | Hearing Loss/Stem Cells | Regenerate hair cells using support cells |
| Decibel Tx (Boston) | Growth factors/ Hidden hearing loss and tinnitus | Growth factors |
| Sensorion (Montpellier) | Vertigo (Labyrinthitis), hearing loss (sudden & chemotherapy)/Receptor antagonists | Histamine receptor anatogonist for vestibulopathy (SENS-111) 5-HT3 receptor antagonist for sudden hearing loss (SENS-401) Hearing loss associated with cisplatin traetment |
| Spiral Tx (San Fran) | Prevent chemotherapy-induced hearing loss/ Anti-apoptotic agent | Prevent hair cell death during cancer treatment (LPT99) Use novel drug delivery systems |
| OtoStem | Stem cells | |
| Acousia Tx (Tübingen) | Hearing loss/Small molecules for hair cell regeneration | otopotin – dedifferentiates supporting cells, redifferentiate into hair cell and supporting cell in vitro |
| Otologic Phx | Drug Cocktail/Acute hearing loss RNAi/hair cell regeneration | Acute noise &blast injury (HPN-07&NAC: NHPN-1010) RNAi for hair cell regeneration in inner ear (OPI-001) |
| Affichem | ?/Drug | Sudden hearing loss and noise-induced hearing loss (AF243) |
| Oricula Rx | Ototoxicity-induced hearing loss/ | Preserve hearing during aminoglycoside therapy (ORC-13661) |
| Pragma Tx | mGlu7-related/Drug | |
| Silence Tx | Drug | With a name like that, they should be an ear company |
| Akouos | Virus-Delivered Therapy/Sensorineural hearing loss | Adeno-associated viral vector-based gene therapy for sensorineural hearing loss |
| OtolithLabs (Wash DC) | Masking/Diziness, vertigo and nausea | Suppress diziness, vertigo and nausea with external device |
| OtoMagnetics (Wash DC) | Outer to middle and middle to inner ear drug delivery system/Drug-eluting nanoparticles | Active drug delivery system, can handle most any drug |
| Cocoon Biotec (Boston) | Middle&inner ear Drug delivery/Silk | Act as a drug reservoir for drugs to diffuse from middle ear to inner ear |
| Otonomy (San Diego) | Drug delivery to inner ear/Long lasting gel | Tinnitus (OTO-313 gacyclidine)
Hidden hearing Loss (OTO-413 BDNF/growth factor) CIHL (OTO-510 otoprotectant) Severe hearing loss (OTO-6 hair cell regeneration) |
| Novus Tx (Irvine) | Middle Ear Infections/Drug combination | Nasal spray with surfactant - Middle ear infection (OP0201) |
| O-Ray Phx (Los Angeles) | Drug delivery/hearing loss | Sensineural hearing loss
(OR-102) Meniere’s Disease (OR-105) Ototoxicity (OR-107) |
| Sound Phx (Seattle) | Noise&Drug induced hearing loss/ Oral Ebselen | Acute noise-induced hearing loss (SPI-1005) Menière's disease (SPI-1005/Ebselen) Ototoxic drugs (SPI-3005/Ebselen & allopurinol) |
| Auris Medical (Basel) | Hearing loss, Tinnitus, Vertigo/Drug | Acute tinnitus (AM-101/Keyzilen or Esketamine)
Acute inner ear hearing loss (AM-111/brimapitide) Vertigo (AM-125/intranasal betahistine) |
| Autifony | Hearing loss/Drug | AUT00063 |
| GenVec/Novartis | Hearing loss/Gene | CGF166 (Atoh1 gene) |
| Fennec | Pediatric hearing loss/Drug | PedmarkVR (sodium thiosulfate) |
| Condition | ||
|---|---|---|
| Hearing | ||
| Tinnitus | ||
| Balance | ||
| Ménière's |
| Entity | Title | DATE | Status |
|---|---|---|---|
| Frequency Tx | FX-322 in Sensorineural Hearing Loss
| Oct 2018 | Active, not recruiting
|
| Sound Pharma | |||
| NAME | Type | Date | Location |
|---|---|---|---|
| Association for Research in Otolaryngology | Research | Feb 10-13 | Baltimore MD |
| COSM | Medical | May 1-5 | Austin, TX |
| International Hearing Loss | Research | May 5-9 | Niagara/Lake, ON, Canada |
| Acoustical Society of America | Research | May 10-13 | Louisville, KY |
| Bellucci Symposium on Hearing Research | Research | May 10 | Omaha |
| World Congress of Otology | Medical | May 28-Jun 1 | Warsaw |
| Binaural brainstem and beyond | Research | Jun 11-12 | Oldenburg |
| Tinnitus & Hyperacusis | Patients/care providers | Jun 13-14 | U Iowa |
| Research | Jun 13-14 | London (UK) | |
| European ORL | Medical | Jun 29-Jul 3 | Bruxelles |
| Midwest Auditory Research Conference | Research | Jul 11-13 | Springfield (IL) |
| Frontiers in hearing: auditory development | Research | Jul 14-16 | Estes Park (CO) |
| EARssentials | Course | Jul 15-19 | Bethesda (MD) |
| Biology of the Inner Ear | Course | Aug 6-28 | Woods Hole (MA) |
| Ribbon synapses Symposium | Research | Sept 2-3 | Göttingen |
| A basic auditory science meeting | General public | Sep 4-5 | UCL, London (UK) |
| NCRAR: ototoxicity and noise damage: preclinical to audiology | Sept 25-27 | Portland (OR) | |
| Hair cell regeneration and hearing restoration | Research | Oct 18 | Chicago |
| APAN 2019 (SfN) | Research | Oct 18 | Chicago |
| 2nd Int’l symposium on inner ear therapeutics | Research/Clinical | Nov 4-6 | Hannover |
| 43rd ARO Annual MidWinter Meeting | Research/Clinical | Jan 24-29 2020 | San Jose |
| 7th Int’l Conf on Auditory Cortex | Research | Jun 6-10 2020 | Magdeburg |
| MEMRO21 (Int’l Symp on middle ear mechanics) | Research/Medical | Jun 23-26 2021 | Boulder (CO) |
| Int'l Conference on Cognitive Hearing for Communication | Research/Public | Jun 9-12 | Linköping (Sweden) |
| Evoked Response Audiometry Study Group Biennial Conference | Research | Jun 30-Jul 4 | Macquarie University (Aus) |
| Minimally Invasive Ear, Nose & Throat Open Forum | Clinical | Jun 20-22 | Boston (MA) |
| Ototoxicity and Noise Damage: Translating Preclinical Findings to Audiological Management | Research/Medical | Sep 25-27 | Portland (OR) |